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KMID : 0390019930030010068
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Pediatric Allergy and Respiratory Disease
1993 Volume.3 No. 1 p.68 ~ p.72
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Antibody response against 65kD heat shock protein in Kawasaki disease
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Abstract
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Kawasaki disease is well known, composed of several clinical symptom complexes which was first reported in 1967. However, the etiology of this disease is still not known. There are many evidences that this disease may be a kind of autoimmune
disease.
Recently, it was reported tat this disease was associated with 65kD heat shock protein (HSP). We tested the sera from acute and subacute phase of its illness which had antibody response against BCG and 65kD HSP extracted from BCG. Antibody titer
against
BCG and 65kD HSP were significantly increased in subacute phase sera compared to that in acute phase sere. We might conclude that 65kD HSP might have a pathogenic role in Kawasaki disease. Further study should be done in this area.
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KEYWORD
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